Fig. 7.

Aldosterone deficiency attenuated HF-feeding-induced adipose tissue macrophage infiltration but not adipocyte hypertrophy. HF feeding increased F4/80 positivity in wild-type mouse epididymal fat tissues but appeared to be less in As^−/− mice (a, diaminobenzidine staining; scale bar 100 μm). Adipocyte size increased significantly and similarly in wild-type and As^−/− mice during HF feeding (b). HF feeding markedly increased the percentage of F4/80-positive macrophages within the adipose tissue in wild-type mice, but this effect was attenuated in As^−/− mice (c). **p≤0.01, ***p≤0.001