Table 3.
Highlighted linkage analysis results (logarithm of odds (LOD) scores with nominal p values)a
| Factor | Peak SNP | All (618 families) | Caucasian (517 families) | ||
|---|---|---|---|---|---|
| No covariate | 4 covariatesc | No covariate | 4 covariatesc | ||
| Factor 1: Joint attention |
Chr11q23: rs723599 (112,377,515 bp)b |
2.93 (p=0.0001) |
3.92 (p=0.00001) |
3.47 (p=0.00003) |
4.00 (p=0.00001) |
| Factor 4: Repetitive sensory- motor behaviour |
Chr19q13: rs895355 (52,822,703 bp)b |
0.98 (p=0.02) |
1.87 (p=0.002) |
2.66 (p=0.0002) |
4.92 (p<0.00001) |
Note: The highest LOD scores are in bold. Bp = base pair; SNP = single nucleotide polymorphism.
For both regions, the linkage analysis results improved after adjustment for covariates (e.g. from 3.47 to 4.00 for the joint attention factor, and from 2.66 to 4.92 for the repetitive sensory-motor behaviour factor using the Caucasian families). Restricting the analysis to the Caucasian families resulted in stronger evidence for linkage at 19q13.32-q13.33 (from 1.87 to 4.92 with the adjustment for covariates), while the results at 11q23.1-q23.3 changed little (from 3.92 to 4.00).
National Center for Biotechnology Information (NCBI) build 35.
After adjustment for 4 covariates: gender, age at Autism Diagnostic Interview-Revised (ADI-R) assessment, age squared, and verbal/nonverbal status.