Figure 3.

A) A schematic depiction of a multimodality contrast agent with Au core providing contrast for CT and additional labels for fluorescent imaging (Rhodamine) and MRI (Gd) in the phospholipid coating. Fluorescence (B), CT (C) and MRI (D) phantoms demonstrating the contrast generating properties of the nanoparticle. E) MR images of an atherosclerotic mouse aorta pre- and 24 hours post-injection with AuNPs. F) Confocal microscopy image of the atherosclerotic plaque of a mouse, where nanoparticles are red, macrophages are green and nuclei are blue. Arrowheads indicate colocalization of nanoparticles and macrophages. Figure adapted, with permission, from reference ⁸².