Table 4.

Mixed-effects model of neuropsychological performance over 2 years

Effect	F statistica	P
Delayed memory
Age	14.77	<0.001
Education	9.82	0.003
Time	2.03	0.14
Group	25.92	<0.001
Group × time	0.89	0.42
Information processing speed/executive function
Age	12.26	<0.001
Education	8.31	0.005
Time	0.27	0.77
Group	24.93	<0.001
Group × time	0.21	0.81
Language
Age	0.58	0.45
Education	23.03	<0.001
Time	0.31	0.73
Group	4.61	0.036
Group × time	3.57	0.034
Visuomotor ability
Age	2.93	0.09
Education	10.75	0.002
Time	5.19	0.008
Group	11.84	0.001
Group × time	0.33	0.72
Global score
Age	7.65	0.007
Education	14.81	<0.001
Time	1.70	0.19
Group	22.83	<0.001
Group × time	0.64	0.53

^aDegrees of freedom=1,65 for age, education and group and 2,65 for time and group × time.