Table 2.
Protein sequence identities between the 26 non-vaccine emm-types that were opsonized and 30-valent vaccine proteins.a
| Non- vaccine emm-type |
30-Valent Vaccine Sequence Identity |
% Identity |
30-Valent Vaccine Sequence Identity |
% Identity |
30-Valent Vaccine Sequence Identity |
% Identity |
|---|---|---|---|---|---|---|
| 25.1 | Emm58.0 (2-37)b | 50 | Emm87.0 (1-33) | 52.9 | Emm82.0 (1-38) | 41 |
| 65.0 | Emm44.0 (4-40) | 75.7 | Emm11.0 (16-50) | 54.1 | Emm118.0 (17-48) | 43.8 |
| 109.1 | Emm28.0 (10-50) | 72.7 | Emm22.0 (19-50) | 90.6 | Emm4.0 (13-50) | 50 |
| 42.0 | Emm11.0 (20-50) | 71.9 | Emm44.0 (11-46) | 56.8 | Emm81.0 (12-35) | 58.3 |
| 64.4 | Emm83.1 (2-48) | 55.3 | Emm24.0 (23-33) | 54.5 | ||
| 74.0 | Emm14.3 (3-49) | 55.3 | Emm29.2 (3-43) | 39 | Emm19.0 (38-50) | 46.2 |
| 85.1 | Emm11.0 (6-50) | 87.5 | Emm44.0 (10-46) | 59.5 | Emm81.0 (12-44) | 48.5 |
| 95.0 | Emm82.0 (22-29) | 75 | ||||
| 123.0 | Emm83.1 (30-48) | 73.7 | Emm4.0 (10-32) | 56.5 | Emm29.2 (23-40) | 55.6 |
| st1731.1 | Emm78.0 (5-50) | 68.8 | Emm22.0 (1-50) | 51.1 | Emm4.0 (19-50) | 54.5 |
| st2904.2 | Emm118.0 (24-50) | 76.9 | Emm49.0 (29-50) | 73.9 | Emm44.0 (14-41) | 46.4 |
| 8.0 | Emm78.0 (1-50) | 66 | Emm4.0 (42-49) | 87.5 | Emm78.0 (15-27) | 53.8 |
| 63.0 | Emm4.0 (18-37) | 57.9 | Emm44.0 (16-47) | 45.2 | Emm11.0 (21-50) | 45.2 |
| 79.0 | Emm87.0 (4-50) | 70.2 | Emm58.0 (3-40) | 57.9 | Emm82.0 (4-41) | 42.1 |
| 97.1 | Emm3. 1 (41-50) | 70 | Emm114.0 (28-34) | 71.4 | ||
| stKNB.6 | Emm49.0 (8-50) | 97.7 | Emm118.0 (8-50) | 78.7 | Emm89.0 (15-41) | 55.6 |
| st1389.0 | Emm22.0 (31-37) | 62.5 | Emm58.0 (10-17) | 62.5 | Emm3. 1 (45-48) | 100 |
| 69.1 | Emm44.0 (3-39) | 75.7 | Emm11.0 (16-50) | 54.1 | Emm118.0 (17-48) | 43.8 |
| 71.1 | Emm5.14 (1-25) | 53.8 | Emm18.0 (28-50) | 59.1 | ||
| 53.4 | Emm83.1 (30-50) | 76.2 | Emm18.0 (31-42) | 66.7 | Emm29.2 (23-39) | 47.1 |
| 60.0 | Emm78.0 (5-38) | 58.8 | Emm22.0 (1-31) | 68.8 | Emm89.0 (25-37) | 69.2 |
| 100.2 | Emm18.0 (4-46) | 44.2 | Emm24.0 (1-50) | 40.8 | Emm18.0 (30-50) | 56.5 |
| 111.0 | Emm83.1 (32-41) | 50 | Emm22.0 (24-34) | 54.5 | Emm19.0 (36-45) | 60 |
| st2460.0 | Emm58.0 (27-50) | 75 | Emm83.1 (31-40) | 80 | Emm58.0 (29-50) | 40.9 |
| stXH1.0 | Emm11.0 (24-37) | 92.9 | Emm92.0 (10-46) | 51.4 | Emm44.0 (9-26) | 66.7 |
| st2911.0 | Emm18.0 (40-49) | 60 | Emm83.1 (18-40) | 43.5 | Emm4.0 (21-28) | 75 |
a
Sequence identities for regions of vaccine peptides of fewer than seven consecutive amino acids were not tabulated, thus some fields are blank.
b
Emm designates the peptide fragment within the 30-valent protein that shares identity with the N-terminal 50 amino acid sequence of the M protein from the non-vaccine emm-type. The numbers in parentheses indicate the amino acid sequence locations within the peptides that exhibit the sequence identities.