Fig. 6. AP-1 Complex mediates inflammatory signaling via TLR3 and MAP3K8.
A. JUN and FOS knockdown by siRNA dramatically alters gene expression of TLR3 in C. pneumoniae infected HCAEC and THP-1 cells as measured by qRT-PCR.
B. Expression of AP-1 components correlates with MAPK signaling pathway during C. pneumoniae infection of HCAEC measured by both microarray and qRT-PCR.