Table 1.

Putative Roles for Mammalian TRP Channels in Drug Abuse

Mammalian Channel	Brain Region/Pathway	Putative Role(s)	References
TRPA1	Nociceptive Pathways	Withdrawal Pain Nicotine Dependence	Bang et al., 2007 Talavera et al., 2009
TRPC1	Nucleus Accumbens Prefrontal Cortex	Synaptic Plasticity	Kim et al., 2003
TRPC3	Striatum	Synaptic Plasticity Nicotine Dependence	Berg et al., 2007 Feng et al., 2006 Jia et al., 2007
TRPC4	Thalamus	Dendritic Neurotransmission	Cavalie, 2007 Uhl et al., 2008
TRPC5	Nucleus Accumbens Amygdala	Appetitive Processing CS-US Associations	Riccio et al., 2009 Schafe et al., 2005
TRPC7	Striatum	Synaptic Plasticity	Beirut et al., 2007 Berg et al., 2007 Lessov-Schlagger et al., 2008 Numaga et al., 2007
TRPM5	Gustatory Pathways	Peripheral CS Processing	Gulbransen et al., 2008 Oliveira-Maia et al., 2009
TRPM8	Nociceptive Pathways	Peripheral CS Processing Ethanol Dependence	Benedickt et al., 2007 Willis et al., 2011
TRPV1	Prefrontal Cortex Striatum Amygdala	Synaptic Plasticity Ethanol Dependence	Benedickt et al., 2007 Blednov & Harris, 2009 Grueter et al., 2010 Kauer & Gibson, 2009 Liu et al., 2004 McClung & Hirsch, 1998 McClung & Hirsch, 1999 Tian et al., 2010 Venkatachalam & Montell, 2007