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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: J Mol Cell Cardiol. 2013 Jan 18;57:59–67. doi: 10.1016/j.yjmcc.2013.01.006

Fig. 2. Infusion of Ang-II to mice deficient in TNFR1 did not induce interstitial fibrosis in the heart.

Fig. 2

Tissue sections were stained with picrosirius red (image magnification: x100) after 1 week of continuous Ang-II treatment (n=5–6/group) and collagen deposition was evaluated in the left ventricle. Control mice received saline (n=3/group). A) In contrast to their corresponding wild-type mice (B6129), mice deficient in both TNF receptors (TNFR1R2-KO) were protected from Ang-II exposure, as interstitial collagen deposition was lower than in wild-type mice and comparable to saline values. B) Mice deficient in TNFR1 (TNFR1-KO) did not develop interstitial collagen deposition in response to Ang-II when compared to their corresponding wild-type group (C57) or to mice deficient in TNFR2 (TNFR2-KO), the latter two not being different from each other (see also Suppl. Fig. 2). *P<0.05 between Ang-II- and saline-treated groups (same genetic background). #P<0.05 compared to Ang-II-treated wild-type group. NS = no significant difference.