Table 1.
Baseline characteristics comparing children with virologic success versus virologic failure
| Characteristics | Number of children* |
Overall cohort n=100 Median (IQR) or N (%) |
Virologic success n = 66 Median (IQR) or N (%) |
Virologic failure n = 66 Median (IQR) or N (%) |
p-value# |
|---|---|---|---|---|---|
| Age (years) | 100 | 4.5 (2.6, 6.2) | 4.7 (2.9, 6.7) | 3.3 (2.2, 5.7) | 0.07 |
| Female | 100 | 53 (53%) | 36 (55%) | 17 (50%) | 0.67 |
| Lost one or both parents | 100 | 28 (28%) | 17 (26%) | 11 (32%) | 0.49 |
| Hospitalized pre-ART | 99 | 69 (69%) | 46 (70%) | 23 (68%) | 1.00 |
| WHO clinical stage 3–4 | 97 | 86 (89%) | 59 (89%) | 27 (79%) | 0.35 |
| Weight-for-age z-score | 98 | −2.3 (−3.0, −1.4) | −2.3 (−3.2, −1.4) | −2.3 (−2.8, −1.7) | 0.75 |
| Weight-for-height z-score | 92 | −1.1 (−1.9, −0.2) | −1.2 (−1.9, −0.2) | −1.0 (−1.9, −0.3) | 0.98 |
| Height-for-age z-score | 97 | −2.2 (−3.1, −1.2) | −2.1 (−3.5, −1.2) | −2.4 (−3.0, −1.0) | 0.86 |
| CD4 count cells/µl | 99 | 344 (102, 666) | 300 (82, 650) | 387 (156, 666) | 0.27 |
| CD4 cell percent | 97 | 6.8 (3.7, 11.4) | 6.6 (3.3, 10.9) | 7.0 (3.8, 13.0) | 0.53 |
| HIV-1 RNA log10 copies/ml | 100 | 6.0 (5.5, 6.4) | 5.9 (5.3, 6.5) | 6.1 (5.7, 6.4) | 0.10 |
| Haemoglobin g/dl | 99 | 10.3 (9.2, 11.7) | 10.2 (9.0, 11.8) | 10.4 (9.7, 11) | 0.58 |
| Started on Efavirenz | 100 | 34 (34%) | 26 (39%) | 8 (24%) | 0.11 |
| Started on ZDV | 100 | 75 (75%) | 51 (77%) | 24 (71%) | 0.47 |
| Adherence <100% | 100 | 60 (60%) |
*
number of children with data for each baseline characteristic included in the analysis
#
p-value compares children with viral success to those with viral failure