TABLE 1.

Results of microarray analysis in 293.CREB-HΔTMC for genes differentially regulated after the addition of Dox to induce CREB-HΔTMC. Assays were performed in triplicate at 12h and 24h after Dox addition and analysed on Affymetrix Human Gene 1.0 ST arrays. Genes with an FDR-adjusted p-value of less than 0.05 are considered as differentially expressed and the table indicates a selection of these genes with changes in gene expression over 1.5x, grouped on the basis of potential pathways or function. A table of the full complement of differentially regulated genes is attached in Supplementary Table 1. These genes were also analysed using the David Bioinformatic Resource for Gene Ontogeny using a multiple linkage threshold of 0.5, a cut-off EASE score of probability of 0.01. This analysis is presented in Supplementary Table 2

List of oligonucleotides used for Drosophila fly strain construction

CREB3L3 FGW	5′	CACCATGAATACGGATTTAGCTGCTGG	3′
CREB3L3 RGW	5′	TTAACAGGTGCCTGTCTGGGCTGA	3′
CREB3L4 FGW	5′	CACCATGGATCTCGGAATCCCTGACCTG	3′
CREB3L4 RGW	5′	CTAGCTGGTCTGGGCAGCTTTGTTGG	3′
CREB3 FGW	5′	CACCATGGAGCTGGAATTGGATGCTGG	3′
CREB3 RGW	5′	CTATATCTCAATCACCATGGCCTGGAG	3′