Figure 6.
Use of reovirus-based therapy for the prevention of PC development. (a) Female C57BL/6 mice were implanted with 3 × 106 ID8 cells on day 0 and then injected with a regimen of PBS/UVRV/LRV injections as shown in the schematic. The animals were monitored for the development of (b) ascites and (c) survival. The graphs show the cumulative data on the average days post-tumor implantation when ascites was first detected in respective groups of animals. Statistical analysis was performed through intergroup comparison using Student's t-tests at 95% CI; ns = P > 0.05; *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001. CI, confidence interval; i.p., intraperitoneally; LRV, live reovirus; ns, not significant; PBS, phosphate-buffered saline; PC, peritoneal carcinomatosis; UVRV, UV-inactivated reovirus.