Skip to main content
. Author manuscript; available in PMC: 2014 Mar 28.
Published in final edited form as: J Control Release. 2013 Jan 7;166(3):227–233. doi: 10.1016/j.jconrel.2012.12.029

Fig. 2.

Fig. 2

Evaluating in vivo transfection efficiency of nanoparticle mRNA and naked mRNA administered intranasally. (A) Bioluminescence in C57BL/6 mice transfected intranasally with 4 μg of p/mLuc and n/mLuc over a 24 hour time period. NTC-: Non Transfected Control, no luciferin injected; NTC+: Non Transfected Control, luciferin injected; p/mOVA: mOVA nanoparticle (B) Representative set of IVIS images of nasally transfected mice 4 h post-intranasal delivery: (i) p/mLuc (ii) n/mLuc in NaAc Buffer (iii) n/mLuc in Ringer’s Lactate. Fifth mouse in panels (i) to (iii) is NTC+. *** p<0.0001 compared to p/mOVA, NTC- and NTC+ based on one-way anova (all 15 groups) followed by bonferroni multiple comparison test. * p<0.05 based on two tailed student’s t-test.