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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Transgenic Res. 2012 Aug 1;22(2):403–410. doi: 10.1007/s11248-012-9637-8

Fig 3.

Fig 3

Notch4 activation in VE-cadherin cells leads to embryonic vascular remodeling defects. The Notch4ICD transgenic strain was crossed to VE-cadherin-Cre to generate VE-cadherin-Cre; Notch4ICD embryos. Litters were analyzed to compare controls (no N4ICD transgene) to embryos with N4ICD expression at E13.5 (a), E14.5 (b), and E16.5 (c). The embryos with activated Notch4 signaling showed vascular hemorrhaging and defective vascular structure. The dotted areas in the upper panels are shown below at higher magnification