Table 3.

Area under the receiver operating characteristic (ROC-AUC) curves for individual and combined tumor marker assays for Stage I and Stage II-IV endometrial cancers.

Marker Combination	ROC-AUC (95% CI) (Controls vs. Endometrial Cancers)
	Stage I	p-value for comparison of ROC-AUC to HE4	Stages II-IV	p-value for comparison of ROC-AUC to HE4
CA125	63.8% (57.1 - 70.4)	0.0009	75.3% (67.1 - 83.6)	0.1125
HE4	76.7% (70.8 - 82.5)	---	83.6% (75.3 - 91.9)	---
CA72.4	50.9% (44.4 - 57.8)	<0.0001	65.3% (56.6 - 74.0)	0.0013
SMRP	51.8% (44.9 - 58.7)	<0.0001	52.6% (42.8 - 62.4)	0.0001
CA125 + HE4	76.7% (70.9 - 82.6)	0.9693	86.6% (79.3 - 94.0)	0.0157
CA125 + CA72.4	63.1% (56.4 - 69.7)	0.0004	76.5% (68.6 - 84.5)	0.1386
CA125 + SMRP	63.6% (56.9 - 70.2)	0.0007	78.2% (70.3 - 86.1)	0.3524
HE4 + CA72.4	76.9% (71.1 - 82.7)	0.5167	83.6% (75.3 - 91.9)	0.8103
HE4 + SMRP	76.7% (70.9 - 82.5)	0.7413	87.4% (81.1 - 93.7)	0.0496
CA125 + HE4 + CA72.4	76.9% (71.0 - 82.7)	0.9898	86.3% (78.8 - 93.8)	0.0268
CA125 + HE4 + SMRP	76.8% (70.9 - 82.6)	0.9170	89.8% (84.2 - 95.3)	0.0087
CA125 + CA72.4 + SMRP	62.8% (56.0 - 69.5)	0.0003	78.9% (71.2 - 86.6)	0.3943
HE4 + CA72.4 + SMRP	76.9% (71.1 - 82.7)	0.6121	87.1% (80.6 - 93.5)	0.0794
CA125 + HE4 + CA72.4 + SMRP	76.9% (71.1 - 82.8)	0.9631	89.3% (83.6 - 95.0)	0.0132