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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Comp Immunol Microbiol Infect Dis. 2012 Nov 26;36(2):113–128. doi: 10.1016/j.cimid.2012.10.005

Figure 8.

Figure 8

Protection of mice immunized as newborns with Sal-F1 and Sal-LcrV. Mice were immunized as described in Fig. 7 and challenged i.n. or i.v. with Y. pestis EV76 4-5 weeks after the last immunization. (A) Survival curves from mice challenged with 2.3×104 CFU (1,150 MLD50) i.v. or (B) with 6.2×106 CFU (4.7 MLD50) i.n. (C and D) Health scores (mean values) following i.v. or i.n. infection. (E and F) Weight assessment after i.v. or i.n. infection; results are expressed as the mean percent of initial weight (mean values). The dotted line indicates the time point of the last death in the control group, which was used for group comparisons (*p<0.05).