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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Comp Immunol Microbiol Infect Dis. 2012 Nov 26;36(2):113–128. doi: 10.1016/j.cimid.2012.10.005

Table 1.

Immunization protocols to validate the Y. pestis EV76 i.v. and i.n. infection models

Age at (weeks old)
 Route of administration
 Challenge
dose
Groups Prime Boost Challenge Iron Y. pestis EV76
Adults
(n=5)		 8 11 17 i.p. i.v. 3,150 MLD50
(2.3×105CFU)
Adults
(n=5)		 8 11 17 i.n. i.n. 15.8 MLD50
(1.5×108CFU)
Neonates
(n=5-6)		 1 3 7 i.p. i.v. 1,150 MLD50
(2.3×104CFU)
Neonates
(n=5-6)		 1 3 8 i.n. i.n. 4.7 MLD50
(6.2×106CFU)