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. Author manuscript; available in PMC: 2014 Mar 15.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Jan 30;23(6):1612–1616. doi: 10.1016/j.bmcl.2013.01.106

Figure 2.

Figure 2

Kinetics of [11C]4F-MHPG and [18F]4F-MHPG in the isolated rat heart. A 10-min constant infusion study assesses the neuronal uptake rate of the tracer into sympathetic nerve terminals, after which the heart is switched back to normal heart perfusate to study clearance rates. Both tracers exhibit very long neuronal retention times due to sequestration inside norepinephrine storage vesicles.