Figure 2. Amino acid substitution matrix of selected core haloarchaeal orthologous proteins for invariant negatively and positively charged and polar and small non-polar residues in mesophilic versus corresponding cold-adapted H. lacusprofundi proteins.

Amino acids conserved in 604 protein families in 12 mesophilic sequences are indicated on the right-axis, H. lacusprofundi amino acids are on left-axis, and the number of amino acid substitutions on the vertical axis, with higher peaks (>10) colored for emphasis.