Figure 3. Amino acid substitution matrix of selected core haloarchaeal orthologous proteins for invariant non-polar residues in mesophilic versus cold-adapted H. lacusprofundi proteins.

Amino acids conserved in 604 protein families in 12 mesophilic sequences are shown on the right-axis, H. lacusprofundi amino acids are on left-axis, and the number of amino acid substitutions on the vertical axis, with higher peaks (>10) colored for emphasis.