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. 2013 Mar 11;8(3):e58855. doi: 10.1371/journal.pone.0058855

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© 2013 Zhou et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Effects of casticin on ROS generation (A and B) and the effects of NAC on casticin-induced DR5 and CHOP upregulation (C) using western blot analysis and TRAIL-mediated apoptosis (D) in BGC-823 cells (mean±SD, n = 3). ^* P<0.05 vs. treatment with DMSO; ^# P<0.05 vs. treatment with 1 µmol/l casticin plus 50 ng/ml TRAIL in cells pretreated with NAC.