Table 3. Genes included in functional annotation clusters in gene group of 5-HTT KO mice in conditions acute stress vs. control as acquired by DAVID tool.

Cluster	Transcript	Gene Title	Symbol	FC1	Effect	P-Value
glycoprotein; transport	10454192	transthyretin	Ttr	5.92	up	0.024
membrane; transport	10356403	potassium inwardly-rectifying channel, subfamily J, member 13	Kcnj13	5.82	up	0.007
glycoprotein; plasma membrane; membrane	10527870	klotho	Kl	3.45	up	0.015
glycoprotein	10351224	coagulation factor V; similar to Murine coagulation factor V	F5	2.83	up	0.016
glycoprotein	10395389	sclerostin domain containing 1	Sostdc1	2.71	up	0.028
glycoprotein; transport	10478048	lipopolysaccharide binding protein	Lbp	2.38	up	0.040
membrane	10547191	transmembrane protein 72	Tmem72	2.1	up	0.033
glycoprotein	10347277	insulin-like growth factor binding protein 2	Igfbp2	2.06	up	0.032
glycoprotein	10569344	insulin-like growth factor 2	Igf2	2.05	up	0.043
glycoprotein; plasma membrane; membrane; transport	10436947	potassium voltage-gated channel, Isk-related subfamily, gene 2	Kcne2	2.04	up	0.035
glycoprotein; plasma membrane; membrane; transport	10495712	ATP-binding cassette, sub-family A (ABC1),member 4	Abca4	2.04	up	0.029
glycoprotein	10440091	collagen, type VIII, alpha 1	Col8a1	2.01	up	0.021
plasma membrane; membrane; transport	10436958	chloride intracellular channel 6	Clic6	1.98	up	0.003
glycoprotein; plasma membrane; membrane	10600024	G-protein-coupled receptor 50	Gpr50	1.95	up	0.050
plasma membrane; membrane	10602033	claudin 2	Cldn2	1.94	up	0.023
glycoprotein; plasma membrane; membrane	10428619	ectonucleotide pyrophosphatase/phosphodiesterase 2	Enpp2	1.92	up	0.031
glycoprotein; membrane; transport	10362104	solute carrier family 2 (facilitated glucosetransporter), member 12	Slc2a12	1.91	up	0.016
glycoprotein; plasma membrane; membrane	10456005	CD74 antigen	Cd74	1.87	up	0.021
glycoprotein; plasma membrane; membrane	10506301	leptin receptor	Lepr	1.86	up	0.034
glycoprotein; plasma membrane; membrane	10450154	histocompatibility 2, class II antigen A, alpha	H2-Aa	1.85	up	0.019
glycoprotein; plasma membrane; membrane	10466606	annexin A1	Anxa1	1.85	up	0.023
glycoprotein; plasma membrane; membrane	10381962	angiotensin I _raline_ne enzyme(peptidyl-dipeptidase A) 1	Ace	1.81	up	0.016
glycoprotein; membrane	10423049	prolactin receptor	Prlr	1.76	up	0.035
glycoprotein	10357870	_raline arginine-rich end leucine-rich repeat	Prelp	1.69	up	0.048
glycoprotein; plasma membrane; membrane	10362896	CD24a antigen	Cd24a	1.68	up	0.044
glycoprotein	10542993	paraoxonase 3	Pon3	1.66	up	0.036
plasma membrane; membrane; transport	10532839	transient receptor potential cation channel,subfamily V, member 4	Trpv4	1.65	up	0.039
glycoprotein; plasma membrane; membrane; transport	10538459	aquaporin 1	Aqp1	1.61	up	0.040
membrane	10422728	disabled homolog 2 (Drosophila)	Dab2	1.59	up	0.026
membrane	10373588	retinol dehydrogenase 5	Rdh5	1.58	up	0.015
glycoprotein	10344897	sulfatase 1	Sulf1	1.57	up	0.034
glycoprotein	10541354	alpha-2-macroglobulin	A2m	1.52	up	0.048
glycoprotein; membrane	10511180	matrix-remodelling associated 8	Mxra8	1.52	up	0.006
glycoprotein; membrane	10584653	C1q and tumor necrosis factor related protein 5	C1qtnf5	1.51	up	0.028
glycoprotein	10536220	collagen, type I, alpha 2	Col1a2	1.5	up	0.034
glycoprotein; plasma membrane; membrane; transport	10366391	potassium voltage gated channel, Shaw-related subfamily, member 2	Kcnc2	1.54	down	0.030

¹Abbreviation: FC, fold change.