Table 3. Genes included in functional annotation clusters in gene group of 5-HTT KO mice in conditions acute stress vs. control as acquired by DAVID tool.
Cluster | Transcript | Gene Title | Symbol | FC1 | Effect | P-Value |
glycoprotein; transport | 10454192 | transthyretin | Ttr | 5.92 | up | 0.024 |
membrane; transport | 10356403 | potassium inwardly-rectifying channel, subfamily J, member 13 | Kcnj13 | 5.82 | up | 0.007 |
glycoprotein; plasma membrane; membrane | 10527870 | klotho | Kl | 3.45 | up | 0.015 |
glycoprotein | 10351224 | coagulation factor V; similar to Murine coagulation factor V | F5 | 2.83 | up | 0.016 |
glycoprotein | 10395389 | sclerostin domain containing 1 | Sostdc1 | 2.71 | up | 0.028 |
glycoprotein; transport | 10478048 | lipopolysaccharide binding protein | Lbp | 2.38 | up | 0.040 |
membrane | 10547191 | transmembrane protein 72 | Tmem72 | 2.1 | up | 0.033 |
glycoprotein | 10347277 | insulin-like growth factor binding protein 2 | Igfbp2 | 2.06 | up | 0.032 |
glycoprotein | 10569344 | insulin-like growth factor 2 | Igf2 | 2.05 | up | 0.043 |
glycoprotein; plasma membrane; membrane; transport | 10436947 | potassium voltage-gated channel, Isk-related subfamily, gene 2 | Kcne2 | 2.04 | up | 0.035 |
glycoprotein; plasma membrane; membrane; transport | 10495712 | ATP-binding cassette, sub-family A (ABC1),member 4 | Abca4 | 2.04 | up | 0.029 |
glycoprotein | 10440091 | collagen, type VIII, alpha 1 | Col8a1 | 2.01 | up | 0.021 |
plasma membrane; membrane; transport | 10436958 | chloride intracellular channel 6 | Clic6 | 1.98 | up | 0.003 |
glycoprotein; plasma membrane; membrane | 10600024 | G-protein-coupled receptor 50 | Gpr50 | 1.95 | up | 0.050 |
plasma membrane; membrane | 10602033 | claudin 2 | Cldn2 | 1.94 | up | 0.023 |
glycoprotein; plasma membrane; membrane | 10428619 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | Enpp2 | 1.92 | up | 0.031 |
glycoprotein; membrane; transport | 10362104 | solute carrier family 2 (facilitated glucosetransporter), member 12 | Slc2a12 | 1.91 | up | 0.016 |
glycoprotein; plasma membrane; membrane | 10456005 | CD74 antigen | Cd74 | 1.87 | up | 0.021 |
glycoprotein; plasma membrane; membrane | 10506301 | leptin receptor | Lepr | 1.86 | up | 0.034 |
glycoprotein; plasma membrane; membrane | 10450154 | histocompatibility 2, class II antigen A, alpha | H2-Aa | 1.85 | up | 0.019 |
glycoprotein; plasma membrane; membrane | 10466606 | annexin A1 | Anxa1 | 1.85 | up | 0.023 |
glycoprotein; plasma membrane; membrane | 10381962 | angiotensin I _raline_ne enzyme(peptidyl-dipeptidase A) 1 | Ace | 1.81 | up | 0.016 |
glycoprotein; membrane | 10423049 | prolactin receptor | Prlr | 1.76 | up | 0.035 |
glycoprotein | 10357870 | _raline arginine-rich end leucine-rich repeat | Prelp | 1.69 | up | 0.048 |
glycoprotein; plasma membrane; membrane | 10362896 | CD24a antigen | Cd24a | 1.68 | up | 0.044 |
glycoprotein | 10542993 | paraoxonase 3 | Pon3 | 1.66 | up | 0.036 |
plasma membrane; membrane; transport | 10532839 | transient receptor potential cation channel,subfamily V, member 4 | Trpv4 | 1.65 | up | 0.039 |
glycoprotein; plasma membrane; membrane; transport | 10538459 | aquaporin 1 | Aqp1 | 1.61 | up | 0.040 |
membrane | 10422728 | disabled homolog 2 (Drosophila) | Dab2 | 1.59 | up | 0.026 |
membrane | 10373588 | retinol dehydrogenase 5 | Rdh5 | 1.58 | up | 0.015 |
glycoprotein | 10344897 | sulfatase 1 | Sulf1 | 1.57 | up | 0.034 |
glycoprotein | 10541354 | alpha-2-macroglobulin | A2m | 1.52 | up | 0.048 |
glycoprotein; membrane | 10511180 | matrix-remodelling associated 8 | Mxra8 | 1.52 | up | 0.006 |
glycoprotein; membrane | 10584653 | C1q and tumor necrosis factor related protein 5 | C1qtnf5 | 1.51 | up | 0.028 |
glycoprotein | 10536220 | collagen, type I, alpha 2 | Col1a2 | 1.5 | up | 0.034 |
glycoprotein; plasma membrane; membrane; transport | 10366391 | potassium voltage gated channel, Shaw-related subfamily, member 2 | Kcnc2 | 1.54 | down | 0.030 |
Abbreviation: FC, fold change.