Figure 2. Model sub-structure.

Single arrows represent transitions between health states; looped arrows indicates situations where transition out of a particular disease state is not 100% (i.e. a patient may remain in the disease state); wide arrows represent transitions to or from any state in the central green column to a specific disease/end state. Chronic hepatitis B disease states are based on Ishak fibrosis scores: F0/F1 (mild disease), F2/F3/F4 (fibrosis), >F4 (advanced fibrosis/compensated cirrhosis), decompensated cirrhosis, hepatocellular carcinoma, liver transplant, post-liver transplant. Adverse events/other dynamic disease states include HBsAg loss, HBeAg seroconversion, creatine kinase elevationThe end state is death.