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. 2013 Mar 11;8(3):e57996. doi: 10.1371/journal.pone.0057996

Figure 4. Keratin deficient and wild-type KRAS driven lung tumors have comparable rates of proliferation and apoptosis.

Figure 4

(A) Ki-67 immunohistochemistry of a KII −/− deficient tumor (compare figure 5 from the same series of serial sections). (B) Formal analysis of 6 areas per lung of six Keratin wild-type and KII −/− tumors reveals similar Ki-67 proliferation index. Cleaved caspase 3 staining only showed single positive cells (red arrow) in in Keratin deficient (−/−) and Keratin expressing tumors (KII).