Skip to main content
. 2013 Mar 11;8(3):e58500. doi: 10.1371/journal.pone.0058500

Figure 7. Model of the post-transcriptional regulation of Cx43 expression in normal and transformed cells.

Figure 7

a) In normal cells, the 3′UTR exerts a positive regulation on Cx43 expression. b) Ras-mediated transformation exerts a blockade on a regulatory element (S1516) embedded within the 3′UTR, but releases a positive regulation by the 5′UTR, with a final result of induction of Cx43 expression. c) In human cancer cells, additional oncogenic events inhibit the 5′UTR-mediated regulation, which combined with the S1516-mediated blockade, results in the silencing of Cx43 expression in cancer cells.