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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: J Mol Cell Cardiol. 2013 Jan 8;57:23–31. doi: 10.1016/j.yjmcc.2012.12.022

Figure 1.

Figure 1

One heart from each population is shown to illustrate the relative α- vs β-MyHC isoform content in these heterozygous mice compared to controls. A. In older mice aged 40–60 wks, a significant proportion of β-MyHC, a hallmark of developing cardiomyopathy, was found in the F764L/+ compared to S532P/+ and +/+ controls. B. In younger mice aged 20–30 wks, β-MyHC content was also higher in F764L/+ compared to S532P/+ and +/+ controls. C. Normalized isometric tension vs pCa demonstrated a maximum calcium activated condition at pCa 4.8, 17°C and 2.2 μm sarcomere length used throughout the study. n = number of hearts, two strips per heart.