Figure 5. Severe lung pathology can be predicted.
(a,b) IAV-specific memory cell hierarchies were tested by elispot assay of PBMC on each mouse, 6 wks after immunization. Mice were then challenged with LCMV and lungs were scored at day 7. The relationship between the intensity of lung pathology and the numbers of IAV-specific memory T-cells was evaluated by linear regression. Data was pooled from 3 experiments (n=5-10 mice/gp/expt).