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. Author manuscript; available in PMC: 2014 Mar 15.
Published in final edited form as: J Immunol. 2013 Feb 13;190(6):2736–2746. doi: 10.4049/jimmunol.1201936

Figure 7. Lung pathology prevented by blocking IFNγ activity.

Figure 7

(a,b) IAV-immune mice were either treated with anti-IFNγ (▵) or with PBS (◻) i.v. day 0 and 3 and daily i.p. after LCMV infection. Lung pathology was scored. Photographs of representative examples of lung histology from each group are shown. Data were pooled from 2 experiments (n=3-4 mice/gp/expt). (c,d) Splenocytes were harvested at day 7 after LCMV infection from naïve, IAV-immune (non-depleted) or IAV-immune mice following depletion of IFNγ. LCMV-specific immune responses were characterized by surface staining of CD8, CD44 and in ICS assays examining peptides-specific IFNγ and TNF production.