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. Author manuscript; available in PMC: 2014 Jun 15.
Published in final edited form as: Int J Cancer. 2012 Dec 27;132(12):2940–2947. doi: 10.1002/ijc.27969

Table 2.

Odds ratios and 95% confidence intervals for the association between serum 25(OH)D, DBP, and the 25(OH)D:DBP molar ratio, and risk of prostate cancer, ATBC Study, 1985–2005

Quintile 1 Quintile 2 Quintile 3 Quintile 4 Quintile 5 p-trend
OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI)
25(OH)D
Range a
# cases/# controls 162/190 192/192 197/189 188/185 209/192
   Model 1b 1.00 (reference) 1.27 (0.93–1.72) 1.31 (0.97–1.78) 1.28 (0.93–1.76) 1.45 (1.06–1.99) 0.04
   Model 2c 1.00 (reference) 1.27 (0.93–1.73) 1.32 (0.97–1.79) 1.29 (0.94–1.78) 1.47 (1.07–2.02) 0.03
DBP
Range, nmol/L ≤ 4077 > 4077 & ≤ 5113 > 5113 & ≤ 6058 > 6058 & ≤ 7320 > 7720
# cases/# controls 183/189 229/190 162/189 193/191 181/189
   Model 1b 1.00 (reference) 1.26 (0.93–1.70) 0.88 (0.65–1.19) 1.01 (0.74–1.39) 0.96 (0.70–1.33) 0.40
   Model 2c 1.00 (reference) 1.28 (0.94–1.73) 0.86 (0.64–1.17) 0.99 (0.72–1.36) 0.94 (0.68–1.29) 0.29
25(OH)D:DBP molar ratio (×103) d
Range ≤ 3.24 > 3.24 & ≤ 4.94 > 4.94 & ≤ 7.24 > 7.24 & ≤ 10.52 > 10.52
# cases/# controls 145/189 185/191 249/190 190/190 179/188
   Model 1b 1.00 (reference) 1.32 (0.96–1.80) 1.80 (1.33–2.44) 1.45 (1.04–2.01) 1.36 (0.97–1.91) 0.04
a

Season-specific quintile cutpoints for 25(OH)D were Q1: ≤16.3, Q2: >16.3 and ≤23.8, Q3: >23.8 and ≤33.3, Q4: >33.3 and ≤45.6, Q5: >45.6 nmol/L for the less sunny months (November-April); Q1: ≤25.9, Q2: >25.9 and ≤35.7, Q3: >35.7 and ≤48.3, Q4: >48.3 and ≤59.9, Q5: >59.9 nmol/L for sunnier months (May-October).

b

Model 1 is conditioned on the matching factors and adjusted for age (continuous), family history of prostate cancer (yes, no, missing), and serum α-tocopherol (continuous).

c

Model 2 is the same as Model 1, with additional adjustment for either 25(OH)D or DBP, respectively (continuous).

d

a proxy for free 25(OH)D