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. Author manuscript; available in PMC: 2014 Jun 15.
Published in final edited form as: Int J Cancer. 2012 Dec 27;132(12):2940–2947. doi: 10.1002/ijc.27969

Table 3.

Odds ratios and 95% confidence intervals for the association between serum 25(OH)D, DBP, and the 25(OH)D:DBP molar ratio and risk of prostate cancer – stratified models, ATBC Study, 1985–2005

Quintile 1 Quintile 2 Quintile 3 Quintile 4 Quintile 5 p-trend p-
interaction
OR(95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI)
25(OH)D, nmol/L
Rangea
DBP below median
# cases/# controls 100/105 114/92 99/99 81/96 94/90
    Model 1b 1.00 (reference) 1.43 (0.96–2.13) 1.15 (0.77–1.73) 0.97 (0.64–1.46) 1.22 (0.81–1.84) 0.97 0.04
    Model 2c 1.00 (reference) 1.43 (0.96–2.13) 1.15 (0.77–1.73) 0.97 (0.64–1.47) 1.22 (0.81–1.84) 0.97
DBP above median
# cases/# controls 62/89 78/103 98/92 107/94 117/104
    Model 1b 1.00 (reference) 1.16 (0.74–1.82) 1.68 (1.08–2.61) 1.75 (1.13–2.72) 1.81 (1.18–2.79) 0.001
    Model 2c 1.00 (reference) 1.16 (0.74–1.82) 1.67 (1.07–2.61) 1.75 (1.13–2.71) 1.81 (1.17–2.78) 0.001
DBP
Range, nmol/L ≤ 4077 > 4077 & ≤ 5113 > 5113 & ≤ 6058 > 6058 & ≤ 7320 > 7320
25(OH)D below median
# cases/# controls 99/97 132/106 75/91 81/93 64/99
    Model 1b 1.00 (reference) 1.20 (0.82–1.77) 0.79 (0.52–1.21) 0.82 (0.54–1.25) 0.59 (0.38–0.90) 0.003 0.02
    Model 2c 1.00 (reference) 1.22 (0.83–1.80) 0.80 (0.52–1.22) 0.82 (0.54–1.25) 0.58 (0.38–0.90) 0.002
25(OH)D above median
# cases/# controls 85/96 97/87 87/102 113/100 117/93
    Model 1b 1.00 (reference) 1.28 (0.85–1.95) 0.99 (0.65–1.50) 1.25 (0.83–1.87) 1.47 (0.98v2.20) 0.10
    Model 2c 1.00 (reference) 1.29 (0.85–1.95) 0.99 (0.66–1.51) 1.25 (0.84–1.87) 1.47 (0.98–2.21) 0.10
25(OH)D:DBP molar ratio (×103) d
Range ≤ 3.24 > 3.24 & ≤ 4.94 > 4.94 & ≤ 7.24 > 7.24 & ≤ 10.52 > 10.52
DBP below median
# cases/# controls 51/57 69/68 114/84 112/118 142/155
    Model 1b 1.00 (reference) 1.23 (0.73–2.07) 1.60 (0.98–2.59) 1.18 (0.74–1.90) 1.14 (0.72–1.79) 0.91 0.71
DBP above median
# cases/# controls 94/136 116/125 135/109 79/75 38/37
    Model 1b 1.00 (reference) 1.45 (0.99–2.10) 1.87 (1.29–2.73) 1.62 (1.06–2.48) 1.71 (1.00–2.92) 0.01
a

Season-specific quintile cutpoints for 25(OH)D were Q1: ≤16.3, Q2: >16.3 and ≤23.8, Q3: >23.8 and ≤33.3, Q4: >33.3 and ≤45.6, Q5: >45.6 nmol/L for the less sunny months (November-April); Q1: ≤25.9, Q2: >25.9 and ≤35.7, Q3: >35.7 and ≤48.3, Q4: >48.3 and ≤59.9, Q5: >59.9 nmol/L for sunnier months (May-October).

b

Model 1 is calculated using unconditional regression, adjusted for age (continuous), family history of prostate cancer (yes, no, missing), serum α-tocopherol (continuous), and date of blood collection (continuous).

c

Model 2 is the same as Model 1, with additional adjustment for either 25(OH)D or DBP, respectively (continuous).

d

a proxy for free 25(OH)D