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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: J Inherit Metab Dis. 2012 Sep 13;36(2):235–246. doi: 10.1007/s10545-012-9522-x

Figure 4.

Figure 4

Three dimensional micro-CT reconstructions of knee joints in MPS I, IIIA, IVA, and VII mice. Cross-sections are sagittal through the midline of the knee joint. Arrow 1 shows abnormal periosteal bone formation on the tibia of an MPS I mouse. Arrow 2 shows an area of increased bone thickness in an MPS I mouse compared to the WT control mouse. Arrow 3 shows severe abnormal periosteal bone formation on the tibia of an MPS VII mouse. Arrow 4 shows abnormally thickened bone in an MPS VII mouse compared with the bone thickness in an age-matched WT mouse.