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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: J Inherit Metab Dis. 2012 Sep 13;36(2):235–246. doi: 10.1007/s10545-012-9522-x

Figure 7.

Figure 7

Histopathologic changes of the proximal growth plates (tibia) and articular cartilage area (tibia) at 16 weeks of age. Tissue was stained with toluidine blue. The vacuoles in epiphyseal cartilage layer are more prevalent in order of MPS VII > MPS IVA > MPS I > MPS IIIA mice while the vacuoles in articular cartilage region are more in order of MPS VII > MPS I > MPS IVA > MPS IIIA mice. The perimeters of growth plate and articular cartilage regions are more irregular in MPS VII > MPS I > MPS IVA > MPS IIIA mice.