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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Hepatology. 2013 Feb 7;57(3):1088–1097. doi: 10.1002/hep.26188

Figure1.

Figure1

The expression level of HIF-2α in HCC patients and its clinical significance. (A) Representative images of HIF-2α staining in HCC tissue and corresponding peritumoral tissues. (B) The expression levels of HIF-2α in tumor and corresponding peritumoral tissues. Quantitative analysis of protein levels were determined by measuring the ratio of HIF-2α to GAPDH expression. Error bars indicate the standard deviation (SD).*, p=0.02 by two-tailed test. (C) Quantitative RT-PCR analysis of HIF-2α levels in HCC tissues and corresponding peritumoral tissue. GAPDH was used as a control. Error bars indicate standard deviation (SD) (n=60). *, p<0.001 (two-tailed test). (D) Expression of HIF-2α was examined via immunohistochemistry in 246 hepatocellular carcinoma specimens, and representative images are shown. Scale bar, 10 mm. (E) Kaplan-Meier analysis of overall survival (OS) in 246 HCC patients relative to HIF-2α expression.