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. 2012 Dec 9;68(4):869–880. doi: 10.1093/jac/dks483

Table 2.

IC50 values of phenothiazine-like compounds

Compound Structure IC50 ± SEM (μM)
recombinant Ndh Mtb H37Rv (aerobic) Mtb H37Rv (Wayne model)
Chlorpromazine graphic file with name dks48306.jpg 70.1 ± 9.6 23.7 ± 4.2 11.7 ± 2.5
Flupenthixol graphic file with name dks48307.jpg 28.6 ± 1.7 13.2 ± 1.2 10.0 ± 0.3
Fluphenazine graphic file with name dks48308.jpg 47.8 ± 3.2 14.5 ± 2.3 3.4 ± 0.9
Perphenazine graphic file with name dks48309.jpg 47.5 ± 6.6 18.8 ± 3.6 6.8 ± 1.4
Phenothiazine graphic file with name dks48310.jpg >200 >100 >100
Promazine graphic file with name dks48311.jpg 155.1 ± 17.3 62.1 ± 5.7 10.0 ± 3.8
Promethazine graphic file with name dks48312.jpg 85.3 ± 16.1 50.8 ± 1.6 22.6 ± 4.8
Thioridazine graphic file with name dks48313.jpg 11.4 ± 1.8 13.4 ± 2.1 3.9 ± 0.8
Trifluoperazine graphic file with name dks48314.jpg 15.6 ± 2.2 10.5 ± 1.6 3.6 ± 0.7

Values were calculated spectrophotometrically (recombinant Ndh) or using the MABA assay (Mtb), as described in the Materials and methods section, and are the mean of at least two replicates.