Table 5.
12-month change (mean, 95% CI) in lean mass, appendicular lean mass (ALM) and skeletal muscle index (SMI) among participants, stratified by age.
| Age <60y | Age ≥60 y | ||||
|---|---|---|---|---|---|
| Baseline | 12 month Δ | Baseline | 12 month Δ | ||
| Control | n=62 | n=57 | n=25 | n=23 | |
| lean mass | 40.9 (39.6, 42.2) | 0.02 (−0.56, 0.59) | 39.6 (37.6, 41.7) | −0.23 (−0.75, 0.28) | |
| ALM | 17.4 (16.8, 18.0) | −0.29 (−0.51, −0.07) | 16.6 (15.7, 17.6) | −0.13 (−0.48, 0.22) | |
| SMI | 6.3 (6.1, 6.5) | −0.10 (−0.17, −0.02) | 6.1 (5.9, 6.4) | −0.07 (−0.19, 0.05) | |
| Exercise | n=80 | n=71 | n=37 | n=34 | pinteraction* |
| lean mass | 40.7 (39.5, 41.8) | 0.38 (−0.11, 0.87) | 39.2 (37.7, 40.7) | 0.11 (−0.44, 0.66) | 0.16 |
| ALM | 17.3 (16.8, 17.8) | 0.23 (0.00, 0.45) | 16.7 (16.0, 17.4) | −0.03 (−0.28, 0.22) | 0.67 |
| SMI | 6.3 (6.2, 6.4) | 0.09 (0.00, 0.17) | 6.2 (6.0, 6.4) | 0.02 (−0.12, 0.09) | 0.67 |
| Diet | n=83 | n=74 | n=34 | n=29 | |
| lean mass | 40.9 (39.8, 42.0) | −0.73 (−1.07, −0.39) | 40.3 (38.8, 41.9) | −1.38 (−2.12, −0.63) | 0.54 |
| ALM | 17.3 (16.8, 17.8) | −0.50 (−0.67, −0.33) | 16.7 (16.2, 17.2) | −0.60(−0.90, −0.30) | 0.94 |
| SMI | 6.3 (6.2, 6.5) | −0.19 (−0.25, −0.12) | 6.3 (6.1, 6.5) | −0.26 (−0.38, −0.13) | 0.87 |
| Diet + Exercise | n=79 | n=72 | n=38 | n=36 | |
| lean mass | 39.6 (38.7, 40.5) | −0.36 (−0.78, 0.06) | 39.7 (38.3, 41.1) | −0.70 (−1.39, −0.01) | 0.59 |
| ALM | 16.9 (16.4, 17.3) | −0.11 (−0.29, 0.07) | 16.7 (16.1, 17.3) | −0.45 (−0.77, −0.12) | 0.33 |
| SMI | 6.3 (6.1, 6.4) | −0.03 (−0.10, 0.04) | 6.4 (6.2, 6.7) | −0.16 (−0.28, −0.03) | 0.49 |
Analysis completed using all available data.
*
pinteraction: pvalue comparing difference in baseline to 12 months change in between age strata in each intervention group versus controls, adjusted for ethnicity,