Figure 1.

The putative relationship between obesity, physical inactivity and colorectal tumor evolution pathways by cellular CTNNB1 status, based on the data by the current study and the previous study (17). The current study suggests that energy balance exposures (i.e., obesity and physical activity level) influence CTNNB1-negative colorectal cancer risk, but not CTNNB1-positive cancer risk (left). Our previous data suggest that an energy balance exposure such as physical activity may influence progression of CTNNB1-negative tumor after colorectal cancer diagnosis (right) (17). In contrast, progression of CTNNB1-positive tumors appeared to be independent of energy balance status of patients (17).