Table 5.
Pooled effect sizes (95% confidence interval in parenthesis) of short-term weight gain and metabolic changes in comparison of SGAs and FGAs. A negative effect size and an RR below 1 indicate worse side effects from FGAs.
| SGA | FGA Comparator | Weight Change (Hedges’ g) | Weight Gain (>7%) (RR) | Glucose change (Hedges’ g) | Cholesterol change (Hedges’ g) | Triglyceride change (Hedges’ g) |
|---|---|---|---|---|---|---|
| Olanzapine | Haloperidol | 0.61 (0.35~0.87)** (N=4, n=572) | 3.31 (1.83~5.98)** (N=2, n=362) | 0.08 (−0.17~0.32) (N=3, n=496) | 0.17 (−0.00~0.35) (N=3, n=501) | 0.20 (−0.25~0.65) (N=2, n=280) |
| Olanzapine | Molindone | 1.77 (1.24~2.30)** (N=1, n = 75) | NR | −0.02 (−0.70~0.66) (N=1, n=35) | 1.02 (0.30~1.75)** (N=1, n=35) | 0.51 (−0.20~1.21) (N=1, n=33) |
| Olanzapine | Sulpiride | 3.56 (2.70~4.42)** (N=1, n=53) | NR | −1.21 (−1.79~−0.63)** (N=1, n=53) | 5.12 (4.01~6.23)** (N=1, n=53) | 3.32 (2.49~4.15)** (N=1, n=53) |
| Risperidone | Haloperidol | 0.22 (0.03~0.40)* (N=2, n=443) | 1.61 (1.25~2.09)** (N=2, n=485) | −0.40 (−0.83~0.03) (N=1, n=84) | −0.07 (−0.50~0.36) (N=1, n=84) | −0.03 (−0.47~0.41) (N=1, n=78) |
| Risperidone | Molindone | 0.93 (0.48~1.3)** (N=1, n=81) | NR | 0.03 (−0.55~0.60) (N=1, n=0.92) | −0.46 (−1.04~0.12) (N=1, n=45) | 0.32 (−0.28~0.92) (N=1, n=42) |
| Risperidone | Sulpiride | −3.86 (−4.73~−3.00)** (N=1, n=58) | NR | −1.99 (−2.61~−1.36)** (N=1, n=58) | −1.36 (−1.93~−0.80)** (N=1, n=58) | −1.18 (−1.74~−0.63)** (N=1, n=58) |
| Clozapine | Chlorpromazine | NR | NR | 0.25 (−0.06~0.56) (N=1, n=160) | NR | NR |
| Clozapine | Sulpiride | 4.95 (3.92~5.97)** (N=1, n=59) | NR | −1.54 (−2.12~−0.97)** (N=1, n=59) | 3.07 (2.32~3.82) (N=1, n=59) | 5.02 (3.98~6.05)** (N=1, n=59) |
| Amisulpride | Haloperidol | 0.12 (−0.20~0.43) (N=1, n=155) | NR | −0.03 (−0.30~0.24) (N=1, n=207) | 0.19 (−0.08~0.47) (N=1, n=207) | 0.34 (0.06~0.61)* (N=1, n=207) |
| Quetiapine | Haloperidol | 0.30 (−0.01~0.62) (N=1, n=157) | NR | −0.11 (−0.38~0.16) (N=1, n=207) | −0.03 (−0.30~0.25) (N=1, n=207) | 0.15 (−0.12~0.42) (N=1, n=207) |
| Ziprasidone | Haloperidol | −0.12 (−0.46~0.22) (N=1, n=132) | NR | −0.36 (−0.65~−0.06)* (N=1, n=185) | 0.02 (−0.27~0.31) (N=1, n=185) | 0.10 (−0.19~0.39) (N=1, n=185) |
| Pooled SGAs | Pooled FGAs | 0.65 (0.33~0.98)** (N=7, n=1059) | 2.26 (1.33~3.69)** (N=3, n=733) | −0.20 (−0.61~0.22) (N=6, n=749) | 0.46 (−0.01~0.92) (N=5, n=593) | 0.71 (−0.02~1.44) (N=4, n=371) |
Note:
*
p < .05;
**
p < .01.
RR = Relative Risk.