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15-Lipoxygenase-1 pathway of endothelial cell arachidonic acid (AA) metabolism. 15(S)-hydroperoxyeicosatetraenoic acid (15(S)-HPETE), 15-hydroxy-11,12-epoxyeicosatrienoic acid (15-H-11,12-EETA), 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE), 11,12,15-trihydroxyeicosatrienoic acid (11,12,15-THETA). * 15-H-11,12-EETA and 11,12,15-THETA cause vascular relaxation and function as EDHFs.
