Table 3.
Genes That May Play a Role in the Development of MetS
| Gene symbol |
Gene name | Proposed function | Component condition |
Portion of the harmonizing definition affected |
|---|---|---|---|---|
| LPL | Lipoprotein lipase |
Hydrolyzes triglycerides and participates in the uptake of lipoproteins from circulation |
Cardiovascular | High-density lipoprotein- cholesterol |
| APOE | Apolipoprotein E |
A protein that binds to a receptor to remove lipoproteins from circulation |
Cardiovascular | High-density lipoprotein- cholesterol |
| MC4R | Melanocortin receptor 4 |
A membrane- bound receptor that interacts with adrenocorticotropic hormones |
Obesity | Waist circumference |
| FTO | Fat mass and obesity associated |
Exact physiological function unknown |
Obesity | Waist circumference |
| TCF7L2 | Transcription factor 7-like 2 |
Transcription factor that is involved in blood glucose homeostasis |
Type 2 diabetes | Glucose |