Fig. 1.

Changes of platelet count in patients with multiple medical treatments. (A) In case 1, the pateint recurred severe thrombocytopenia and recieved methylpredinoslone pulse therapy for 3 days and intravenous immunoglobulin (IVIG) for 5 days. She did not respond these medications and started low-dose intravenous cyclophosphamide (IV CYC) therapy. She achieved remission of thrombocytopenia after the first IV CYC therapy, and a stable platelet count was maintained. (B) In case 2, the platelet count of patient was decreased below 10,000/µL and received methylpredinoslone pulse therapy and IVIG. However, this combination treatment showed no efficacy. The platelet count was increased above 50,000/µL after three cycles of IV CYC, and it remained at stable level. Doses of steroids are presented according to the potency of prednisolone. MP pulse therapy, intravenous methylprednisolone pulse therapy (1,000 mg/day for 3 days); IVIG, intravenous immunoglobulin; IV CYC, intravenous infusion of low-dose cyclophosphamide.