Table 1.
Post-transcriptional processes |
LncRNA | Target | Comments | References |
---|---|---|---|---|
Splicing | MALAT1 | Pre-mRNAs regulated by SR proteins | Modulation of splicing patterns | [17] |
sno-lncRNAs | Pre-mRNAs regulated by Fox proteins | Modulation of splicing patterns | [30] | |
mRNA Turnover | ½-sbsRNAs | mRNAs bearing Alu sequences, Staufen-1 targets | Increase in mRNA decay | [18] |
BACE1-AS | BACE1 mRNA | Increase in mRNA stabilization | [19] | |
Translation | lincRNA-p21 | JUNB and CTNNB mRNAs | Inhibition translation (specific mRNAs) | [21] |
AS Uchl1 | Uchl1 mRNA | Promotion of translation (specific mRNA) | [36] | |
BC1 | eIF4A and PABP | Modulation of translation (global) | [20] | |
miRNA Function | Linc-MD1 | Decoy for miR-133 and miR-135 | Increased translation of MAML1 and MEF2C mRNAs | [38] |
H19 | Gives rise to miR-675 | Decreased expression of IGF1R mRNA (miR-675 target) | [40] | |
BACE1-AS | BACE1 mRNA | Competition with miR-485-5p for binding to BACE1 mRNA | [34] |