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. Author manuscript; available in PMC: 2014 Mar 15.
Published in final edited form as: J Immunol. 2013 Feb 1;190(6):2756–2766. doi: 10.4049/jimmunol.1202697

Figure 1. XID mice exhibit enhanced survival and control of SchuS4 replication compared to WT mice.

Figure 1

Mice were intranasally infected with 50 CFU F. tularensis strain SchuS4. As indicated, animals received 5 mg/kg levofloxacin (LVF) on days 3–16 of infection. CBA/J (WT) and CBA/CaHN-BtkXID/J (XID) mice were monitored for survival (A) or euthanized at the indicated time points for assessment of bacterial loads in the lung and spleen (B and C; n=4–5 mice/group/time point). (A) represents the results of two experiments pooled together. (B) is representative of two experiments of similar design. * = significantly less than WT mice (p<0.05). Error bars represent SEM.