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. Author manuscript; available in PMC: 2014 Mar 15.
Published in final edited form as: J Immunol. 2013 Feb 1;190(6):2756–2766. doi: 10.4049/jimmunol.1202697

Figure 7. B1a cells contribute to exacerbation of SchuS4 infection.

Figure 7

B1a cells were collected from the peritoneal cavities of CBA/J (wild type) mice and enriched by FACS. One day prior to infection XID mice (n=4–5/group) were injected with freshly isolated wild type B1a cells or PBS (untreated). Mice were intranasally infected with 50 CFU F. tularensis strain SchuS4. Animals received 5 mg/kg levofloxacin on days 3–6 of infection. (A) Mice were euthanized on day 7 of infection and bacteria were enumerated from the lung and spleen. (B) Survival of mice receiving B1a cells versus untreated controls. * = significantly different untreated controls (p<0.05). Error bars represent SEM. Data is representative of three experiments of similar design.