Mice were treated with anti-asialo GM1 (anti-AGM1) antibodies to deplete NK/NKT cells or rabbit immunoglobulin (Ig) as a negative control on days −2, +1, +4, +7, +10. +13, +16, +19 of infection. Mice were intranasally infected with 50 CFU F. tularensis strain SchuS4. Animals received 5 mg/kg levofloxacin on days 3–6 of infection. All mice were euthanized on day 7 and 21 of infection and bacteria were enumerated from the lung and spleen. * = significantly different Ig treated controls (p<0.05). Error bars represent SEM. Data is representative of two experiments of similar design.