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. Author manuscript; available in PMC: 2014 Mar 4.
Published in final edited form as: Mol Pharm. 2013 Feb 19;10(3):1056–1062. doi: 10.1021/mp300512r

Figure 5.

Figure 5

Apparent permeability values of the ileum of TgCYP3A4/hPXR mice for darunavir (100 μM) using FaSSIF as perfusate medium. Experiments were performed in control mice, mice orally treated with rifampicin (10 mg/kg) for 3 days and mice orally treated with rifampicin (10 mg/kg) + sulforaphane (5 mg/kg) for 3 days. Statistical significance between the different conditions was evaluated using one way ANOVA followed by Dunnett′s test. *, significantly different from control condition (p < 0.05). Parts of these data have been shown in Figure 3.