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. 2013 Feb 20;168(5):1182–1200. doi: 10.1111/bph.12065

Figure 4.

Figure 4

Co-application of ICA-110381 and RTG has a synergistic effect. (A) Tail currents recorded from individual CHO cells expressing KCNQ2 under control conditions, after bath application of 0.2 μM ICA-11038 (ICA), 0.2 μM ICA plus 0.5 μM retigabine (RTG) and after washout. (B) Tail currents recorded from another CHO cells expressing KCNQ2 under control conditions and in the presence of 0.5 μM RTG. (C) Deactivation times fitted monoexponentially from tail currents at −120 mV after a hyperpolarizing pulse of −40 mV under control conditions in the presence of 0.2 μM ICA, in the presence of 0.5 μM RTG and in the presence of 0.2 μM ICA and 0.5 μM RTG. (D) Conductance–voltage activation curves under control conditions, after application of 0.2 μM ICA, after application of 0.5 μM RTG and after co-application of 0.2 μM ICA and 0.5 μM RTG. (E) Example whole-cell currents recorded from individual CHO cells expressing KCNQ2 under control conditions and after bath application of 20 μM RTG and after additional application of 0.5 ICA-11038.