Figure 6.
ICA-110381 alters intrinsic properties of hippocampal CA1 pyramidal neurons. (A) The voltage responses of a neuron to injection of a current ramp at the soma, under control conditions (left), after 10–15 min bath application of 10 μM ICA-110381 (right). (B) The resting membrane potential (RMP), the input resistant (Rinput), the voltage and current threshold in individual neurons under control conditions and after bath application of ICA-110381. (C) Representative recordings of the neuronal voltage response to sinusoidal current injection with constant peak to peak amplitude and linear increasing frequency (0–20 Hz). (D) Resulting impedance profile of the representative recordings. (E) Quantitative analysis of the mean resonance frequency, the corresponding Q-value and the impedance at hyperpolarized potential, at rest and at depolarized potential. Asterisks denote significance levels of P < 0.05 (*), P < 0.01 (**) and P < 0.001 (***).