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. 2013 Feb 20;168(5):1255–1265. doi: 10.1111/bph.12016

Figure 8.

Figure 8

Potent concentrations of FX-5043 and JK-5 are non-selective for nNOS in intact tissues. (A) FX-5043 (abbreviated FX) or JK-5 (100 μM; 90 min pre-incubation) abolished the NMDA-evoked cGMP response (P > 0.05 compared with basal). The vehicle (dimethyl sulphoxide, DMSO) had no effect (P > 0.05 compared with control). (B) In aortic rings prepared from the same animals as used in panel A and pretreated with IBMX (1 mM, 20 min), ACh (10 μM, 1 min) initiated a significant increase in cGMP (P < 0.001). At the same concentrations as used in panel A (100 μM, 90 min), FX-5043 and JK-5 blocked the cGMP response to ACh (P > 0.05 compared with basal levels). DMSO alone had no effect (P > 0.05 compared to control). Statistics are anova with Tukey–Kramer test. Numbers above error bars indicate n-values.