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. Author manuscript; available in PMC: 2014 Feb 12.
Published in final edited form as: J Am Coll Cardiol. 2012 Dec 5;61(6):599–610. doi: 10.1016/j.jacc.2012.08.1021

Figure 3. Mitochondrial Iron as a Promising Therapeutic Target.

Figure 3

Functional and structural damage to the mitochondria is a prominent feature of HF. In addition to generating ATP, mitochondria play a key role in regulation of cellular iron balance through the synthesis of heme and iron sulfur clusters. However, accumulation of iron in the mitochondria can catalyze generation of ROS and exacerbate damage. Reducing mitochondrial iron through development of mitochondria-permeable iron chelators can potentially protect the failing hearts.