Table 3.
The Characteristics of Selected Endolysins.
| Bacteria | Phage | Host | Phage protein | Name (displayed activity) | Reference(s) |
|---|---|---|---|---|---|
| C1 phage | S. pyogenes | modular | PlyC (amidase) * | [177, 190] | |
| Dp-1 phage | S. pneumoniae | modular | Pal (amidase) * | [191, 229] | |
| Gram-positive | Cp-1 phage | S. pneumoniae | modular | Cpl-1 (muramidase) * | [192, 230, 231] |
| γ phage | B. anthracis | modular | PlyG (amidase) | [195, 232] | |
| φBcp1 phage | B. anthracis | modular | PlyB (muramidase) * | [233] | |
| B4 phage | B. cereus | modular | LysB4 (L-alanoyl-D-glutamate endopeptidases) * | [234] | |
| BPS13 phage | B. cereus | modular | LysBPS13 (amidase) | [235] | |
| φA118 phage | L. monocytogenes | modular | Ply118 (L-alanoyl-D-glutamate peptidase) | [170, 187, 236] | |
| φA511 phage | L. monocytogenes | modular | Ply511 (amidase) | [170, 236] | |
| φA500 phage | L. monocytogenes | modular | Ply500 (L-alanoyl-D-glutamate peptidass) | [170, 187] | |
| NCTC 11261 phage | S. agalactiae | modular | PlyGBS (endopeptidase, muramidase) | [196] | |
| φB30 phage | S. agalactiae | modular | GBSlysine (endopeptidase, glycosidase) | [237, 238] | |
| φP68 phage | S. aureus | modular | Lys16 (endopeptidase, amidase) | [239] | |
| Phi Twort | S. aureus | modular | PlyTW (amidase)* | [240] | |
| φ11 phage | S. aureus | modular | Lysϑ11 (amidase, peptidase)* | [241- 243] | |
| φMR11 phage | S. aureus | modular | MV-L (amidase) | [198] | |
| φH5 phage | S. aureus | modular | LysH5 (amidase, peptidase) | [244] | |
| φK phage | S.aureus | modular | LysK (amidase, endopeptidase) * | [180, 245, 246] | |
| GH15 phage | S. aureus | modular | LysGH15 (amidase) | [200] | |
| SAP-1 phage | S.aureus | modular | SAL-1 (amidase, peptidase) | [246] | |
| P-27/HP phage | S. aureus | modular | P-27/HP lysin | [247] | |
| vB_SauS-φIPLA88 | S. aureus | modular | HydH5 (lysozyme, peptidase) | [248] | |
| 2638A phage | S. aureus | modular | 2638A endolysin (peptidase, amidase) | [249] | |
| φSMP phage | S. suis | modular | LySMP (endopeptidase, glycosidase) | [250] | |
| φWMY M phage | S. warneri | modular | LysWMY (amidase, peptidase) * | [251] | |
| φ1 phage | E. faecalis | modular | PlyV12 (amidase) | [193] | |
| EFAP-1 phage | E. faecalis | modular | EFAL-1 (amidase) | [252] | |
| φEF24C phage | E. faecalis | modular | ORF9 (amidase) | [253] | |
| F168/08 phage | E. faecalis | modular | Lys168 (peptidase) | [254] | |
| F170/08 phage | E. faecalis | modular | Lys170 (amidase) | [254] | |
| φ-0303 phage | L. helveticus | modular | Mur-LH (muramidase) * | [194] | |
| mu1/6. | S. aureofaciens | modular | mu1/6Lyt (amidase) | [255] | |
| CMP1 phage | C. michiganensis | modular | LysCMP1peptidase | [256] | |
| CN77 phage | C. michiganensis | modular | LysCN77peptidase | [256] | |
| φ3626 phage | C. perfringens | modular | Ply3626 (amidase) | [257] | |
| φCD27 phage | C. perfringens | modular | CD27L (amidase) * | [258] | |
| φCP39O phage | C. perfringens | modular | PlyCP39O (amidase) | [259] | |
| φCP26F phage | C. perfringens | modular | PlyCP26F (amidase) | [259] | |
| φCTP1 phage | C. tyrobutyricum | modular | CTP1gp29 (amidase) | [260] | |
| φSM101 phage | C. perfringens | modular | Psm (muramidase) | [261] | |
| Gram-negative | φAB2 phage | A. baumannii | modular | LysAB2 | [262] |
| 201φ2-1 phage | P. chlororaphis | modular | 201ϑ2-1gp229 (goose-like lysozyme) | [182] | |
| φKZ phage | P. aeruginosa | modular | KZ144 (lytic transglycosylase and lysozyme) | [166, 178] | |
| EL phage | P. aeruginosa | modular | EL188 (lytic transglycosylase) | [166] | |
| PaP1 | P. aeruginosa | modular | PaP1_gp072 (unknown enzymatic function) | [263] | |
| φKMV | P. aeruginosa | modular | KMV36C (muramidase) | [264] | |
| OBP phage | P. fluorescens | modular | OBPgp279 (lysozyme) | [182] | |
| PVP-SE1 phage | S. enterica | modular | PVP-SE1gp146 (lysozyme) | [182] | |
| SPN1S phage | S. Typhimurium | modular | SPN1S endolysin (lysozyme) | [265] | |
| BcepC6B phage | B. cepacia | globular | BcepC6gp22 (lytic transglycosylase) | [181] | |
| T5 phage | E. coli | globular | LysT5 (peptidase)* | [266] | |
| P2 phage | E. coli | globular | P2gp09 (lytic transglycosylase) | [181] | |
| PsP3 phage | S. enterica | globular | PsP3gp10 (lytic transglycosylase) | [181] | |
| K11 phage | K. pneumoniae | globular | K11gp3.5 (amidase) | [181] | |
| KP32 phage | K. pneumoniae | globular | KP32gp15 (amidase) | [181] |
*
endolysins biochemically characterized for the actual peptidoglycan cut site.