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. 2013 Mar 12;4:28. doi: 10.3389/fgene.2013.00028

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Copyright © 2013 Rau, Wisniewski, Orozco, Bennett, Weiss and Lusis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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The entire macrophage dataset has a greater number of non-linear interactions. Histograms comparing distributions of Pearson correlations for interactions with high (>0.9) MIC scores. All distributions were sampled such that there were 360 entries for each entry. The blue border in each part of the figure is the liver dataset. (A) Full macrophage dataset vs. liver dataset. (B) Control macrophage vs. liver. (C) Treated macrophage vs. liver. We observe an enrichment for low Pearson correlation data with high MIC scores (implying significant non-linearity) in the full macrophage set which is not observed in either the control, treated, or liver datasets.